Biochemical Cycles demonstrating toxic effects on Metabolism
The following was captured from the Genova Nutreval test
CoFactors are substances that support a particular biochemical processes in the body.
Toxins are substances that inhibit certain biochemical processes in the body
Above is a small portion of a biochemical cycle involving carbohydrate metabolism. In order for Pyruvic Acid to convert into Acetyl CoA, you need the CoFactors listed in the green dot. As long as you have Magnesium (Mg), B1, B2, B3 and Lipoate, you should be able to manufacture Acetyl CoA. Toxins however invalidate this conversion process. The pinkish dot and the red line with the arrow though it represents things that inhibit the conversion from taking place. As, Hg, and Sb represent Arsenic, Mercury and Antimony. Presence of those toxins will likely inhibit this step regardless of ample CoFacors. The presence of toxins debilitates person’s ability to be able to make use of the nutrients they are consuming.
Acetyl CoA is a main factor in cellular respiration known as the Krebs Cycle, which produces energy for the cell. Acetyl CoA is also needed to convert Serotonin to Melatonin as seen below. Toxic inhibition of this process may result in insomnia, and the addition of dietary Melatonin would be ineffective as this conversion needs to take place within the brain, and Melatonin will not cross from the gut and blood to the brain.
The following was taken from the Genova Nutreval Test [Mercury inhibition added]
Mercury (Hg) is particularly toxic. It toxifies one of the main detoxification mediums, namely methlyation. In order to detoxify a fat soluble toxin, a CH3 group called a methyl group needs to be conjoined to the toxin. Mercury disables this process. Now, not only can the body not clear the Mercury, but becomes ineffective as clearing other toxins as well. So the Lead, Cadmium, Organic Phosphates and so on cannot be cleared. Mercury is also a factor is the above as Mercury will interfere with the adenylation of Methionine which creates endogenous Sam-E, another factor important in the conversion of Serotonin to Melatonin.
Sam-E also is needed in the conversion of Norepinephrine to Epinephrine as shown in the next cycle below. Build up of Norepinephrine results anxious states, and a relatively constant unwavering type of anxiety is a typical presentation of Mercury toxicity.
"I don't feel comfortable using a substance designated by the Environmental Protection Agency to be a waste disposal hazard. I can't throw it in the trash, bury it in the ground, or put it in a landfill, but they say it is OK to put it in people's mouths. That doesn't make sense." - Richard. Fischer, D.D.S.
Taken from the Genova Nutreval